FAQs: Polynucleotides in Aesthetic Medicine

Written by Sophie Brooks : Last updated 12 February 2025

Polynucleotide injections are the latest breakthrough in regenerative aesthetics, offering deep skin rejuvenation and cellular repair.

Unlike traditional fillers or skin boosters, polynucleotides work at a DNA level to enhance skin quality, boost collagen production, and restore hydration. Whether you’re looking to improve fine lines, acne scarring, or overall skin health, this treatment provides a natural and long-lasting solution.

In this FAQ, I answer all your key questions about polynucleotides—what they are, how they work, and why they could be the perfect addition to your skincare routine.

Before & After Polynucleotide treatments

• What are polynucleotides?

  Polynucleotides are naturally occurring molecules derived from DNA and RNA that promote cellular repair, hydration, and regeneration. They work by stimulating fibroblasts, increasing collagen and elastin production, and improving skin quality at a deep level.

• How do polynucleotides benefit the skin?

  Polynucleotides improve hydration, elasticity, and skin texture while reducing inflammation and oxidative stress. They are particularly beneficial for treating fine lines, dull skin, acne scars, and general skin ageing.

• Who is a good candidate for polynucleotide treatment?

  Anyone looking to improve skin quality, hydration, and repair is a good candidate. This includes individuals with signs of ageing, sun damage, acne scarring, or those who want to enhance post-procedure recovery.

• How do polynucleotides differ from skin boosters like Profhilo?

  Unlike hyaluronic acid-based skin boosters, which primarily hydrate and plump, polynucleotides actively regenerate skin cells, repair tissue, and have anti-inflammatory properties. They provide long-term skin rejuvenation rather than just hydration.

• Are polynucleotides suitable for all skin types?

  Yes! Polynucleotide treatments are safe for all skin tones and types, including sensitive and reactive skin. They are particularly beneficial for those with rosacea or inflammatory skin conditions.

• What areas can be treated with polynucleotides?

  Polynucleotides can be used on the face, neck, décolletage, hands, and even the under-eye area to improve skin texture and reduce fine lines.

• How many treatments are needed for the best results?

  Most clients benefit from a course of 3-4 treatments spaced 2-4 weeks apart, with maintenance treatments every 6-12 months.

• Can polynucleotides be combined with other treatments?

  Absolutely! Polynucleotides work well alongside LED light therapy, microneedling, and laser treatments to enhance overall skin health and rejuvenation.

• Are there any side effects or downtime?

  Common side effects include mild swelling, redness, or bruising at the injection sites, which typically resolve within a few days. There is minimal downtime, and most clients return to daily activities immediately

• Are polynucleotides inclusive for trans and neurodivergent clients?

  Yes! Polynucleotide treatments can support skin health for all clients, and adjustments can be made to ensure a sensory-friendly and affirming experience.